Brakes utlize friction to slow vehicle tires. Drum brakes employ a cast iron drum that roates with the vehicle axle. When hydraulic pressure is applied to the brake assemblies at the wheels, internal pistons expand and push brake shoes outward into contact with the brake drum slowing the rotation of the axle. More powerful disc brakes operate by pinching a rotating disc betweeen two brake pads and allow for a larger surface area to contact the disc, provide more force, and are more easily cooled.

Cylinder number and arrangement depends on the purpose of the engine. Smaller (four and six cylinder) engines in front-wheel drive vehicles often use an inline design which orients cylinders vertically over the crankshaft and aligns them in a row. Other common orientations are a horizontal/opposed design which places cylinders flat facing each other with the crankshaft between them and a V-type design common in six and eight cylinder engines that features one cylinder head per block of cylinders oriented at a 60 to 90 degree angle to each other with the crankshaft at the bottom of the V.

Power brakes multiply the force a driver applies to the brake pedal using a vacuum booster connected to the engine intake manifold. This provides for much higher hydraulic pressure in the braking system than could be generated by the driver alone. Antilock brakes (ABS) use speed sensors and adjust the brake pressure at each wheel to prevent skidding and allow the driver more steering control in slippery conditions.

A differential is designed to drive a pair of wheels while allowing them to rotate at different speeds. A transaxle is a transmission that incorporates the differential in one package. Most front-wheel drive cars use a transaxle while rear-wheel drive cars use a transmission and separate differential connected via a drive shaft. The differential is incorporated into the drive axle which splits engine power delivered by the drive shaft between the two drive wheels. All-wheel drive cars typically use a transaxle that includes an output shaft to the rear differential.

The transfer case splits engine power between the front and rear axles of four-wheel drive vehicles.