Cylinder number and arrangement depends on the purpose of the engine. Smaller (four and six cylinder) engines in front-wheel drive vehicles often use an inline design which orients cylinders vertically over the crankshaft and aligns them in a row. Other common orientations are a horizontal/opposed design which places cylinders flat facing each other with the crankshaft between them and a V-type design common in six and eight cylinder engines that features one cylinder head per block of cylinders oriented at a 60 to 90 degree angle to each other with the crankshaft at the bottom of the V.

The stroke cycle of an engine is governed by the crankshaft which serves to regulate the firing order of the cylinders. All cylinders are not on the same stroke at the same time and correct firing order is important to balance engine operation and minimize vibrations. A common firing order for four-cylinder engines is 1-3-4-2 which indicates that cylinders 1 and 3 fire (power stroke)together and cylinders 4 and 2 fire together.

A differential is designed to drive a pair of wheels while allowing them to rotate at different speeds. A transaxle is a transmission that incorporates the differential in one package. Most front-wheel drive cars use a transaxle while rear-wheel drive cars use a transmission and separate differential connected via a drive shaft. The differential is incorporated into the drive axle which splits engine power delivered by the drive shaft between the two drive wheels. All-wheel drive cars typically use a transaxle that includes an output shaft to the rear differential.

A water jacket is a coolant-filled casing that allows heat transfer from the engine block and cylinder heads to the liquid coolant.

The wheel hub is the mounting point for the wheel and tire assembly. The wheel hub can rotate while being held stable by the steering knuckle which applies the motion of the control arms to the wheels.