The biosphere is the global ecological system integrating all living beings and their relationships. This includes their interactions with the lithosphere (the rigid outer part of the earth, consisting of the crust and upper mantle), hydrosphere (all surface water), and atmosphere (the envelope of gases surrounding the planet).

To provide oxygen to the body, blood flows through the heart in a path formed by the right atrium → right ventricle → lungs → left atrium → left ventricle → body. When blood enters the right side of the heart it is deoxygenated. It enters the left side of the heart oxygenated after traveling to the lungs.

Below domain, life is classified into six kingdoms: plants, animals, archaebacteria, eubacteria, and fungi. The last kingdom, protists, include all microscopic organisms that are not bacteria, animals, plants or fungi. (Archaebacteria and eubacteria are sometimes combined into a single kingdom, monera.)

In the mesosphere, temperature again drops as altitude increases until the coldest point in the Earth's atmosphere, the mesopause, is reached where temperatures fall to −225 °F (−143 °C).

Veins carry blood back to the heart from the body. While arteries are thick-walled because they carry oxygenated blood at high pressure, veins are comparatively thin-walled as they carry low-pressure deoxygenated blood. Like the heart, veins contain valves to prevent blood backflow.