catastrophic
The definition for catastrophic is "Relating to extreme misfortune." Used in a sentence: The effects of the massive hurricane were catastrophic.
defiant
The definition for defiant is "Showing bold resistance." Used in a sentence: The defiant toddler refused to leave the park.
placebo
The definition for placebo is "An inactive substance used in medical testing." Used in a sentence: Tom, who had taken the placebo, found that his allergy symptoms did not go away.
proximity
The definition for proximity is "Closeness." Used in a sentence: The proximity of Tia's house to school meant that she could walk there in five minutes.
unscrupulous
The definition for unscrupulous is "Lacking principles." Used in a sentence: The unscrupulous salesman was fired for lying to his customers.