Inline cylinder arrangements number cylinders sequentially (1, 2, 3, ...) front to rear.

Cylinder number and arrangement depends on the purpose of the engine. Smaller (four and six cylinder) engines in front-wheel drive vehicles often use an inline design which orients cylinders vertically over the crankshaft and aligns them in a row. Other common orientations are a horizontal/opposed design which places cylinders flat facing each other with the crankshaft between them and a V-type design common in six and eight cylinder engines that features one cylinder head per block of cylinders oriented at a 60 to 90 degree angle to each other with the crankshaft at the bottom of the V.

The wheel hub is the mounting point for the wheel and tire assembly. The wheel hub can rotate while being held stable by the steering knuckle which applies the motion of the control arms to the wheels.

Maintaining proper synchronization between the rotation of the camshaft and the rotation of the crankshaft is critical to ensure that the engine's valves open and close at the proper times during each cylinder's intake and exhaust strokes.

An overcooled engine is less efficient. During the power stroke, combustion heat pushes down the piston. If too much of this heat is lost to the cooling system, the fuel might not combust completely and contaminate the engine's lubricating oil diminishing its lubricating ability. Incomplete combustion of fuel also negatively affects the engine's fuel efficiency and power output.