A differential is designed to drive a pair of wheels while allowing them to rotate at different speeds. A transaxle is a transmission that incorporates the differential in one package. Most front-wheel drive cars use a transaxle while rear-wheel drive cars use a transmission and separate differential connected via a drive shaft. The differential is incorporated into the drive axle which splits engine power delivered by the drive shaft between the two drive wheels. All-wheel drive cars typically use a transaxle that includes an output shaft to the rear differential.

The electric fuel pump feeds pressurized fuel through a fuel filter to the fuel injectors via the fuel rail manifold. The fuel rail contains the fuel pressure regulator which ensures that the fuel injectors receive fuel at a consistent and known rate. Excess fuel bled off by the pressure regulator returns to the fuel tank through the fuel return line.

Maintaining proper synchronization between the rotation of the camshaft and the rotation of the crankshaft is critical to ensure that the engine's valves open and close at the proper times during each cylinder's intake and exhaust strokes.

Power brakes multiply the force a driver applies to the brake pedal using a vacuum booster connected to the engine intake manifold. This provides for much higher hydraulic pressure in the braking system than could be generated by the driver alone. Antilock brakes (ABS) use speed sensors and adjust the brake pressure at each wheel to prevent skidding and allow the driver more steering control in slippery conditions.

Modern car engines are cooled by liquid which circulates through the engine block and cylinder heads absorbing excess heat. This liquid is made up of half water and half antifreeze (commonly, ethylene glycol) which both keeps the water from freezing at low temperatures and raises its boiling point making heat transfer more efficient.