Cylinder number and arrangement depends on the purpose of the engine. Smaller (four and six cylinder) engines in front-wheel drive vehicles often use an inline design which orients cylinders vertically over the crankshaft and aligns them in a row. Other common orientations are a horizontal/opposed design which places cylinders flat facing each other with the crankshaft between them and a V-type design common in six and eight cylinder engines that features one cylinder head per block of cylinders oriented at a 60 to 90 degree angle to each other with the crankshaft at the bottom of the V.

A head gasket is a gasket that sits between the engine block and cylinder heads to seal the cylinders to ensure maximum compression and avoid leakage of coolant or engine oil into the cylinders.

Cylinders act as a guide for the pistons that translate the heat energy of combustion into the mechanical energy necessary to move a vehicle. Piston rings seal the piston to the cylinder to contain combustion gases and also regulate the oil distribution between the piston and cylinder wall. A cylinder head closes in the top of the cylinder forming the combustion chamber which is sealed by a head gasket (head). The head provides space for air and fuel intake valves, exhaust valves, and mounts for spark plugs and fuel injectors.

The intake manifold distributes outside air to the intake ports on the cylinder heads. The intake air filter removes any airborne contaminants before the air enters the engine.

An inline cylinder configuration places the cylinders in a single row either completely vertical or slanted. Due to this arrangement, an inline cylinder configuration makes the engine longer and, although it works well in four cylinder engines, performace suffers in larger engines due to the difficulty in evenly distributing the air-fuel mixture over the length of the engine.