Normal combustion in an engine is initiated by a spark plug and results in the complete burning of the air-fuel mixture. If combustion is initiated by a source other than the spark plug, by a hot spot in the cylinder or combustion chamber for example, pre-ignition results. Detonation results if the air-fuel mixture explodes instead of burning. Detonation can cause extremes in pressure in the combustion chamber leading to engine damage.

The combustion chamber is located in the cylinder head and contains the combustion of the air-fuel mixture. This mixture is delivered by an intake valve and the waste gases from combustion are removed from the combustion chamber by the exhaust valve.

Cylinder number and arrangement depends on the purpose of the engine. Smaller (four and six cylinder) engines in front-wheel drive vehicles often use an inline design which orients cylinders vertically over the crankshaft and aligns them in a row. Other common orientations are a horizontal/opposed design which places cylinders flat facing each other with the crankshaft between them and a V-type design common in six and eight cylinder engines that features one cylinder head per block of cylinders oriented at a 60 to 90 degree angle to each other with the crankshaft at the bottom of the V.

Ignition timing defines the point in time at the end of the compression stroke that the spark plug fires. Measured in number of degrees before top dead center (BTDC), the exact point that the spark plugs initiate combustion varies depending on the speed of the engine. The timing is advanced (the spark plugs fire a few more degrees BTDC) when the engine is running faster and retarded when it's running slower.

During the power stroke, just before the piston reaches top dead center, the spark plug fires and ignites the compressed air-fuel mixture. The resulting expansion due to combustion pushes the piston back down the cylinder toward bottom dead center.