The combustion chamber is located in the cylinder head and contains the combustion of the air-fuel mixture. This mixture is delivered by an intake valve and the waste gases from combustion are removed from the combustion chamber by the exhaust valve.

Cylinder number and arrangement depends on the purpose of the engine. Smaller (four and six cylinder) engines in front-wheel drive vehicles often use an inline design which orients cylinders vertically over the crankshaft and aligns them in a row. Other common orientations are a horizontal/opposed design which places cylinders flat facing each other with the crankshaft between them and a V-type design common in six and eight cylinder engines that features one cylinder head per block of cylinders oriented at a 60 to 90 degree angle to each other with the crankshaft at the bottom of the V.

The stroke cycle of an engine is governed by the crankshaft which serves to regulate the firing order of the cylinders. All cylinders are not on the same stroke at the same time and correct firing order is important to balance engine operation and minimize vibrations. A common firing order for four-cylinder engines is 1-3-4-2 which indicates that cylinders 1 and 3 fire (power stroke)together and cylinders 4 and 2 fire together.

During the power stroke, just before the piston reaches top dead center, the spark plug fires and ignites the compressed air-fuel mixture. The resulting expansion due to combustion pushes the piston back down the cylinder toward bottom dead center.