Cylinder number and arrangement depends on the purpose of the engine. Smaller (four and six cylinder) engines in front-wheel drive vehicles often use an inline design which orients cylinders vertically over the crankshaft and aligns them in a row. Other common orientations are a horizontal/opposed design which places cylinders flat facing each other with the crankshaft between them and a V-type design common in six and eight cylinder engines that features one cylinder head per block of cylinders oriented at a 60 to 90 degree angle to each other with the crankshaft at the bottom of the V.

A half shaft is a drive axle that extends from a transaxle or differential to one of the drive wheels. There are two half shafts per drive axle, one for each wheel, each doing "half" the job.

A differential is designed to drive a pair of wheels while allowing them to rotate at different speeds. A transaxle is a transmission that incorporates the differential in one package. Most front-wheel drive cars use a transaxle while rear-wheel drive cars use a transmission and separate differential connected via a drive shaft. The differential is incorporated into the drive axle which splits engine power delivered by the drive shaft between the two drive wheels. All-wheel drive cars typically use a transaxle that includes an output shaft to the rear differential.

The transmission provides the appropriate power to vehicle wheels to maintain a given speed. The engine and the transmission have to be disconnected to shift gears and a manual transmission requires the driver to manually manage this disconnection (using a clutch) and to manually shift gears. An automatic transmission is essentially an automatic gear shifter and handles this process without driver input.