Blood is created in bone marrow and is made up of cells suspended in liquid plasma. Red blood cells carry oxygen, white blood cells fight infection, and platelets are cell fragments that allow blood to clot.

To provide oxygen to the body, blood flows through the heart in a path formed by the right atrium → right ventricle → lungs → left atrium → left ventricle → body. When blood enters the right side of the heart it is deoxygenated. It enters the left side of the heart oxygenated after traveling to the lungs.

Blood transfer is limited by the type and Rh factor of the blood. Someone who has Rh-factor negative blood cannot receive blood with a positive type but a person with Rh-factor positive type blood can receive Rh-negative blood. Type O negative blood is the universal donor because it can be given to a person with any blood type. Type AB positive is the universal recipient meaning someone with this blood type can receive any other type of blood.

Hard bones provide primary support for the endoskeleton while more flexible cartilage is found at the end of all bones, at the joints, and in the nose and ears. In addition to providing support and protecting bodily organs, bones also produce blood cells and store minerals like calcium.

Tough fibrous cords of connective tissue called tendons connect muscles to the skeleton while another type of connective tissue called ligaments connect bones to other bones at joints (elbow, knee, fingers, spinal column).