To provide oxygen to the body, blood flows through the heart in a path formed by the right atrium → right ventricle → lungs → left atrium → left ventricle → body. When blood enters the right side of the heart it is deoxygenated. It enters the left side of the heart oxygenated after traveling to the lungs.

Blood transfer is limited by the type and Rh factor of the blood. Someone who has Rh-factor negative blood cannot receive blood with a positive type but a person with Rh-factor positive type blood can receive Rh-negative blood. Type O negative blood is the universal donor because it can be given to a person with any blood type. Type AB positive is the universal recipient meaning someone with this blood type can receive any other type of blood.

If no oxygen is present, cellular respiration is anaerobic and will result in fermentation where either lactic acid or alcohol is used instead of oxygen.

In contrast to the Celsius scale (measured in degrees centigrade) that fixes 0° at the freezing point of water and the Fahrenheit scale that uses 32°, the Kelvin scale fixes 0° at absolute zero (-273°C) which is the lowest temperature possible in the universe.