To provide oxygen to the body, blood flows through the heart in a path formed by the right atrium → right ventricle → lungs → left atrium → left ventricle → body. When blood enters the right side of the heart it is deoxygenated. It enters the left side of the heart oxygenated after traveling to the lungs.

If no oxygen is present, cellular respiration is anaerobic and will result in fermentation where either lactic acid or alcohol is used instead of oxygen.

Chemical waste like excess water, minerals, and salt are filtered from the blood by the kidneys and secreted into the urine. Urine is transported from the kidneys to the bladder through ureters.

In the mesosphere, temperature again drops as altitude increases until the coldest point in the Earth's atmosphere, the mesopause, is reached where temperatures fall to −225 °F (−143 °C).

Food is mixed with gastric acid and pepsin in the stomach to help break down protein.