The mechanical advantage of a wheel and axle lies in the difference in radius between the inner (axle) wheel and the outer wheel. But, this mechanical advantage is only realized when the input effort and load are applied to different wheels. Applying both input effort and load to the same wheel results in a mechanical advantage of 1.

A fixed pulley is used to change the direction of a force and does not multiply the force applied. As such, it has a mechanical advantage of one. The benefit of a fixed pulley is that it can allow the force to be applied at a more convenient angle, for example, pulling downward or horizontally to lift an object instead of upward.

Connected gears of different numbers of teeth are used together to change the rotational speed and torque of the input force. If the smaller gear drives the larger gear, the speed of rotation will be reduced and the torque will increase. If the larger gear drives the smaller gear, the speed of rotation will increase and the torque will be reduced.

A screw is an inclined plane wrapped in ridges (threads) around a cylinder. The distance between these ridges defines the pitch of the screw and this distance is how far the screw advances when it is turned once. The mechanical advantage of a screw is its circumference divided by the pitch.

Two or more pulleys used together constitute a block and tackle which, unlike a fixed pulley, does impart mechanical advantage as a function of the number of pulleys that make up the arrangement.  So, for example, a block and tackle with three pulleys would have a mechanical advantage of three.