catastrophic
The definition for catastrophic is "Relating to extreme misfortune." Used in a sentence: The effects of the massive hurricane were catastrophic.
pathos
The definition for pathos is "Sympathetic pity." Used in a sentence: The soldiers cherished the kindly Nurse Nightingale for her pathos.
placebo
The definition for placebo is "An inactive substance used in medical testing." Used in a sentence: Tom, who had taken the placebo, found that his allergy symptoms did not go away.
solace
The definition for solace is "Source of consolation." Used in a sentence: Parents' weekend was a solace to Marjorie, whose beloved daughter had left for college.
turmoil
The definition for turmoil is "Extreme confusion, agitation." Used in a sentence: The windstorm caused such turmoil in the lake that the sailboat capsized.