drub
The definition for drub is "To defeat decisively." Used in a sentence: The powerful young boxer drubbed the longtime champion.
mundane
The definition for mundane is "Practical, ordinary." Used in a sentence: The flighty Caroline could not be troubled with mundane tasks such as paying her bills.
negate
The definition for negate is "To make invalid." Used in a sentence: Paula negated Tiffany's argument by proving that her main premise was false.
placebo
The definition for placebo is "An inactive substance used in medical testing." Used in a sentence: Tom, who had taken the placebo, found that his allergy symptoms did not go away.
preclude
The definition for preclude is "To rule out in advance." Used in a sentence: "Having cake now will preclude dessert later," said Amber's mother.