catastrophic
The definition for catastrophic is "Relating to extreme misfortune." Used in a sentence: The effects of the massive hurricane were catastrophic.
duplicity
The definition for duplicity is "Deceptive thought, speech, or action." Used in a sentence: The life of an undercover detective is filed with necessary duplicity.
extenuating
The definition for extenuating is "Partially excusing." Used in a sentence: The extenuating circumstance of Calvin's illness caused the teacher to excuse his lateness.
mediate
The definition for mediate is "To come between parties in order to reconcile." Used in a sentence: The diplomatic Henry was able to mediate between the quarreling sisters.
negate
The definition for negate is "To make invalid." Used in a sentence: Paula negated Tiffany's argument by proving that her main premise was false.