The definition for mediate is "To come between parties in order to reconcile." Used in a sentence: The diplomatic Henry was able to mediate between the quarreling sisters.

The definition for methodical is "Performed in an orderly manner." Used in a sentence: Oscar's methodical approach exasperated his free–spirited friend Ben.

The definition for onset is "Beginning." Used in a sentence: Crocuses bloom at the onset of spring, sometimes even before the snow melts.

The definition for placebo is "An inactive substance used in medical testing." Used in a sentence: Tom, who had taken the placebo, found that his allergy symptoms did not go away.

The definition for recrimination is "A retaliatory accusation." Used in a sentence: Frank, who was wounded by Sally's remark, made a bitter recrimination.