catastrophic
The definition for catastrophic is "Relating to extreme misfortune." Used in a sentence: The effects of the massive hurricane were catastrophic.
corrosive
The definition for corrosive is "Bitingly sarcastic." Used in a sentence: The cruel Estella's corrosive comments made Pip cry.
elate
The definition for elate is "To fill with joy." Used in a sentence: It elated Margaret to be awarded first place in the science fair.
negate
The definition for negate is "To make invalid." Used in a sentence: Paula negated Tiffany's argument by proving that her main premise was false.
placebo
The definition for placebo is "An inactive substance used in medical testing." Used in a sentence: Tom, who had taken the placebo, found that his allergy symptoms did not go away.