insolence
The definition for insolence is "Boldness or rudeness." Used in a sentence: The boy's insolence to the policeman embarrassed his mother.
liability
The definition for liability is "A person or thing whose presence or behavior is likely to cause embarrassment or put one at a disadvantage." Used in a sentence: Kevin's growing fatigue was a liability as he attempted to climb the steep hill.
onset
The definition for onset is "Beginning." Used in a sentence: Crocuses bloom at the onset of spring, sometimes even before the snow melts.
placebo
The definition for placebo is "An inactive substance used in medical testing." Used in a sentence: Tom, who had taken the placebo, found that his allergy symptoms did not go away.
preclude
The definition for preclude is "To rule out in advance." Used in a sentence: "Having cake now will preclude dessert later," said Amber's mother.