catastrophic
The definition for catastrophic is "Relating to extreme misfortune." Used in a sentence: The effects of the massive hurricane were catastrophic.
heed
The definition for heed is "To pay attention to." Used in a sentence: "Heed my advice," the fortuneteller warned Sebastian when he tried to ignore her prophecy.
melee
The definition for melee is "A tumultuous fight among several people." Used in a sentence: After the game, a melee broke out between fans of the opposing teams.
negate
The definition for negate is "To make invalid." Used in a sentence: Paula negated Tiffany's argument by proving that her main premise was false.
placebo
The definition for placebo is "An inactive substance used in medical testing." Used in a sentence: Tom, who had taken the placebo, found that his allergy symptoms did not go away.