catastrophic
The definition for catastrophic is "Relating to extreme misfortune." Used in a sentence: The effects of the massive hurricane were catastrophic.
futile
The definition for futile is "Without purpose, completely ineffective." Used in a sentence: Arguing with Andrew is futile because he never changes his mind.
inflammatory
The definition for inflammatory is "Tending to excite anger." Used in a sentence: Garth's inflammatory remarks at the party made Gwen furious.
placebo
The definition for placebo is "An inactive substance used in medical testing." Used in a sentence: Tom, who had taken the placebo, found that his allergy symptoms did not go away.
straddle
The definition for straddle is "To favor opposing sides." Used in a sentence: Kia straddled the issue, not wanting to say whether James or Tara was right.