catastrophic
The definition for catastrophic is "Relating to extreme misfortune." Used in a sentence: The effects of the massive hurricane were catastrophic.
futile
The definition for futile is "Without purpose, completely ineffective." Used in a sentence: Arguing with Andrew is futile because he never changes his mind.
negate
The definition for negate is "To make invalid." Used in a sentence: Paula negated Tiffany's argument by proving that her main premise was false.
ramble
The definition for ramble is "To wander, physically or in language." Used in a sentence: Professor Tan rambled during his lectures, frequently straying from the subject.
serenity
The definition for serenity is "Calmness." Used in a sentence: The serenity of the glassy sea soothed the sailors after the big storm.