The definition for appalling is "Inspiring dismay or disgust." Used in a sentence: Hector found his roommate's habit of leaving his dirty socks on the floor appalling.

The definition for placebo is "An inactive substance used in medical testing." Used in a sentence: Tom, who had taken the placebo, found that his allergy symptoms did not go away.

The definition for preclude is "To rule out in advance." Used in a sentence: "Having cake now will preclude dessert later," said Amber's mother.

The definition for rancorous is "Marked by deep ill–will." Used in a sentence: The rancorous competition between the two chess clubs actually ended in a brawl.

The definition for supple is "Flexible." Used in a sentence: The supple leather coat draped like soft cloth around her shoulders.