catastrophic
The definition for catastrophic is "Relating to extreme misfortune." Used in a sentence: The effects of the massive hurricane were catastrophic.
fickle
The definition for fickle is "Lacking constancy, changeable." Used in a sentence: The fickle Senji had a new best friend every month.
flaw
The definition for flaw is "An imperfection." Used in a sentence: The otherwise perfect diamond had a tiny flaw that reduced its value.
futile
The definition for futile is "Without purpose, completely ineffective." Used in a sentence: Arguing with Andrew is futile because he never changes his mind.
interminable
The definition for interminable is "Never ending, or seemingly endless." Used in a sentence: The impatient Zoe found the longwinded lecture interminable.