catastrophic
The definition for catastrophic is "Relating to extreme misfortune." Used in a sentence: The effects of the massive hurricane were catastrophic.
diffident
The definition for diffident is "Lacking self–confidence." Used in a sentence: The diffident student never raised her hand in class, even when she knew the answer.
melee
The definition for melee is "A tumultuous fight among several people." Used in a sentence: After the game, a melee broke out between fans of the opposing teams.
placebo
The definition for placebo is "An inactive substance used in medical testing." Used in a sentence: Tom, who had taken the placebo, found that his allergy symptoms did not go away.
repel
The definition for repel is "To resist, reject." Used in a sentence: The soldiers made a massive charge to repel the invaders.