catastrophic
The definition for catastrophic is "Relating to extreme misfortune." Used in a sentence: The effects of the massive hurricane were catastrophic.
censure
The definition for censure is "To find fault with." Used in a sentence: The critical teacher was quick to censure her students for even small mistakes.
demean
The definition for demean is "To lower status." Used in a sentence: The embarrassing photograph demeaned the candidate in the eyes of the voters.
mandate
The definition for mandate is "An official order or commission to do something." Used in a sentence: Martha reluctantly obeyed the mandate to vacate her apartment.
placebo
The definition for placebo is "An inactive substance used in medical testing." Used in a sentence: Tom, who had taken the placebo, found that his allergy symptoms did not go away.