The definition for diffident is "Lacking self–confidence." Used in a sentence: The diffident student never raised her hand in class, even when she knew the answer.

The definition for egotist is "Self–important person." Used in a sentence: Darren dreaded carpooling with the egotist Shelly, who talked about herself nonstop.

The definition for melodious is "Having a pleasing melody." Used in a sentence: The melodious sounds of the symphony soothed Tim after his trying day.

The definition for onset is "Beginning." Used in a sentence: Crocuses bloom at the onset of spring, sometimes even before the snow melts.

The definition for placebo is "An inactive substance used in medical testing." Used in a sentence: Tom, who had taken the placebo, found that his allergy symptoms did not go away.